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KMID : 0616120210520040228
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Korean Journal of Pharmacognosy
2021 Volume.52 No. 4 p.228 ~ p.233
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Anti-aging Effect of Agarum cribrosum in UVA-irradiated Normal Human Epidermal Keratinocytes
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Shim Joong-Hyun
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Abstract
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This research was carried out to investigate the moisturizing effects of Agarum cribrosum extract on normal human epidermal keratinocytes (NHEKs). Moisturizing effects of A. cribrosum extract on NHEKs were measured by quantitative real-time RT-PCR to verify the gene expressions related to skin hydration, hyaluronic acid (HA)-ELISA to detect HA production, and cell viability assays. A. cribrosum extract increased the mRNA levels of the AQP3 and HAS2 genes and HA production in NHEKs. On the other hand, A. cribrosum extract decreased the mRNA level of the KRT1 and KRT10 genes known as differentiated keratinocyte marker in NHEKs. This research showed the moisturizing effects of A. cribrosum extract. The results indicate that A. cribrosum extract can be a potent functional ingredient for skin hydration and anti-aging products. Further study is warranted regarding the use of A. cribrosum extract to develop not only cosmetics but also food and medicine.
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KEYWORD
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Agarum cribrosum, Hyaluronic acid, AQP3, HAS2, Moisturizing
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